Therapeutic Angiogenesis of PLGA-Heparin Nanoparticle in Mouse Ischemic Limb
نویسندگان
چکیده
منابع مشابه
Therapeutic angiogenesis in ischemic limbs.
In this issue of Circulation, Baumgartner et al 1 report a significant advance in angiogenic gene therapy. The authors induced collateral neovascularization in 10 critically ischemic limbs in 9 patients by the intramuscular gene transfer of naked plasmid DNA encoding the 165-amino-acid isoform of the human angiogenic protein, vascular endothelial growth factor (phVEGF165). The plasmid DNA was i...
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The de-novo formation of vessels (angiogenesis) and the remodelling of preexisting collateral vessels (arteriogenesis) are processes that occur naturally in ischemic heart disease. Promoting these processes by administration of various substances or other physical stimuli (therapeutic angiogenesis) may provide a future strategy for the treatment of ischemic vascular diseases. Mechanisms of angi...
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BACKGROUND Peripheral arterial disease (PAD) is a common disease accounting for about 12% of the adult population, and causes significant morbidity and mortality. Therapeutic angiogenesis using angiogenic factors has been considered to be a potential treatment option for PAD patients. In this study, we assessed the potential of a new angiogenic factor AGGF1 for therapeutic angiogenesis in a cri...
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ژورنال
عنوان ژورنال: Journal of Nanomaterials
سال: 2012
ISSN: 1687-4110,1687-4129
DOI: 10.1155/2012/193704